Using citizen science to expand the global map of landslides: Introducing the Cooperative Open Online Landslide Repository (COOLR).

Robust inventories are very important for enhancing evaluation of and response to lethal and dear landslide hazards. However, accumulating landslide occasions in inventories is troublesome at the global scale due to inconsistencies in or the absence of landslide reporting.

Citizen science is a beneficial alternative for addressing some of these challenges. The new Cooperative Open Online Landslide Repository (COOLR) dietary supplements knowledge in a NASA-developed Global Landslide Catalog (GLC) with citizen science stories to construct a extra strong, publicly accessible global stock.

This manuscript introduces the COOLR venture and its strategies, evaluates the preliminary citizen science outcomes from the first 13 months, and discusses future enhancements to enhance the global engagement with the venture.

The COOLR venture (https://landslides.nasa.gov) accommodates Landslide Reporter, the first global citizen science venture for landslides, and Landslide Viewer, a portal to visualize knowledge from COOLR and different satellite tv for pc and mannequin merchandise. From March 2018 to April 2019, 49 citizen scientists contributed 162 new landslide occasions to COOLR.

These occasions spanned 37 nations in 5 continents. The preliminary outcomes demonstrated that each knowledgeable and novice members are contributing by way of Landslide Reporter. Citizen scientists are filling in knowledge gaps by means of information sources in 11 totally different languages, in-person observations, and new landslide occasions occurring a whole lot and 1000’s of kilometers away from any current GLC knowledge.

The knowledge is of enough accuracy to use in NASA susceptibility and hazard fashions. COOLR continues to expand as an open platform of landslide inventories with new knowledge from citizen scientists, NASA scientists, and different landslide teams.

Future work on the COOLR venture will search to enhance participation and performance of the platform in addition to transfer in direction of collective post-disaster mapping.

Using citizen science to expand the global map of landslides: Introducing the Cooperative Open Online Landslide Repository (COOLR).
Using citizen science to expand the global map of landslides: Introducing the Cooperative Open Online Landslide Repository (COOLR).

10th Anniversary of ALPPS-Lessons Learned and quo Vadis.

OBJECTIVEAssociating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has been examined in numerous indications and scientific situations, main to regular enhancements in security. This report presents the present standing of ALPPS.BACKGROUNDALPPS presents improved resectability, however drawbacks are usually identified concerning security and oncologic advantages.

METHODSDuring the 12th biennial congress of the European African-Hepato-Pancreato-Biliary Association (Mainz, Germany, May 23-26, 2017) an knowledgeable assembly “10th anniversary of ALPP” was held to focus on indications, administration, mechanisms of regeneration, in addition to pitfalls of this novel method. The intention of the assembly was to make a listing of what has been achieved and what stays unclear in ALPPS.

NGLY1 Rabbit pAb

A15864-200ul 200 ul
EUR 550.8

NGLY1 Rabbit pAb

A15864-20ul 20 ul
EUR 219.6

NGLY1 Rabbit pAb

A15864-50ul 50 ul
EUR 267.6

NGLY1 cloning plasmid

CSB-CL853434HU-10ug 10ug
EUR 451.2
Description: A cloning plasmid for the NGLY1 gene.

NGLY1 Polyclonal Antibody

29459-100ul 100ul
EUR 302.4

NGLY1 Polyclonal Antibody

29459-50ul 50ul
EUR 224.4

Rat NGLY1 shRNA Plasmid

20-abx990141
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Chicken NGLY1 ELISA KIT

ELI-16468c 96 Tests
EUR 1113.6

Mouse NGLY1 shRNA Plasmid

20-abx975137
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human NGLY1 shRNA Plasmid

20-abx960904
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

NGLY1 Recombinant Protein (Rat)

RP213884 100 ug Ask for price

NGLY1 Recombinant Protein (Human)

RP021193 100 ug Ask for price

NGLY1 Recombinant Protein (Mouse)

RP154037 100 ug Ask for price

Ngly1 ORF Vector (Rat) (pORF)

ORF071296 1.0 ug DNA
EUR 607.2

NGLY1 ORF Vector (Human) (pORF)

ORF007065 1.0 ug DNA
EUR 114

Ngly1 ORF Vector (Mouse) (pORF)

ORF051347 1.0 ug DNA
EUR 607.2

NGLY1 Polyclonal Conjugated Antibody

C29459 100ul
EUR 476.4

NGLY1 ELISA Kit (Human) (OKCA01408)

OKCA01408 96 Wells
EUR 1015.2
Description: Description of target: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sanadwich ELISA;Sensitivity: 9.38 pg/mL

Human N-Glycanase 1(NGLY1)ELISA Kit

QY-E04736 96T
EUR 433.2

Ngly1 sgRNA CRISPR Lentivector set (Rat)

K6240601 3 x 1.0 ug
EUR 406.8

Ngly1 3'UTR GFP Stable Cell Line

TU164064 1.0 ml Ask for price

NGLY1 3'UTR GFP Stable Cell Line

TU065658 1.0 ml
EUR 1825.2

Ngly1 3'UTR GFP Stable Cell Line

TU263959 1.0 ml Ask for price

NGLY1 sgRNA CRISPR Lentivector set (Human)

K1424901 3 x 1.0 ug
EUR 406.8

Ngly1 sgRNA CRISPR Lentivector set (Mouse)

K3480601 3 x 1.0 ug
EUR 406.8

NGLY1 Protein Vector (Rat) (pPM-C-HA)

PV285184 500 ng
EUR 723.6

NGLY1 Protein Vector (Rat) (pPB-C-His)

PV285182 500 ng
EUR 723.6

NGLY1 Protein Vector (Rat) (pPB-N-His)

PV285183 500 ng
EUR 723.6

NGLY1 Protein Vector (Rat) (pPM-C-His)

PV285185 500 ng
EUR 723.6

NGLY1 Protein Vector (Human) (pPM-C-HA)

PV028259 500 ng
EUR 394.8

NGLY1 Protein Vector (Mouse) (pPM-C-HA)

PV205388 500 ng
EUR 723.6

NGLY1 Protein Vector (Human) (pPB-C-His)

PV028257 500 ng
EUR 394.8

NGLY1 Protein Vector (Human) (pPB-N-His)

PV028258 500 ng
EUR 394.8

NGLY1 Protein Vector (Human) (pPM-C-His)

PV028260 500 ng
EUR 394.8

NGLY1 Protein Vector (Mouse) (pPB-C-His)

PV205386 500 ng
EUR 723.6

NGLY1 Protein Vector (Mouse) (pPB-N-His)

PV205387 500 ng
EUR 723.6

NGLY1 Protein Vector (Mouse) (pPM-C-His)

PV205389 500 ng
EUR 723.6

Ngly1 3'UTR Luciferase Stable Cell Line

TU114064 1.0 ml Ask for price

NGLY1 3'UTR Luciferase Stable Cell Line

TU015658 1.0 ml
EUR 1825.2

Ngly1 3'UTR Luciferase Stable Cell Line

TU213959 1.0 ml Ask for price

Ngly1 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6240602 1.0 ug DNA
EUR 184.8

Ngly1 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6240603 1.0 ug DNA
EUR 184.8

Ngly1 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6240604 1.0 ug DNA
EUR 184.8

NGLY1 sgRNA CRISPR Lentivector (Human) (Target 1)

K1424902 1.0 ug DNA
EUR 184.8

NGLY1 sgRNA CRISPR Lentivector (Human) (Target 2)

K1424903 1.0 ug DNA
EUR 184.8

NGLY1 sgRNA CRISPR Lentivector (Human) (Target 3)

K1424904 1.0 ug DNA
EUR 184.8

Ngly1 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3480602 1.0 ug DNA
EUR 184.8

Ngly1 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3480603 1.0 ug DNA
EUR 184.8

Ngly1 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3480604 1.0 ug DNA
EUR 184.8

NGLY1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV690133 1.0 ug DNA
EUR 818.4

NGLY1 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV690137 1.0 ug DNA
EUR 818.4

NGLY1 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV690138 1.0 ug DNA
EUR 818.4

Recombinant Aspergillus Oryzae NGLY1 Protein (aa 1-457) [His]

VAng-Wyb3999-1mg 1 mg
EUR 6028.8
Description: Aspergillus Oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) N-Glycanase 1, recombinant protein.

Ngly1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K6240605 3 x 1.0 ug
EUR 451.2

NGLY1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K1424905 3 x 1.0 ug
EUR 451.2

Ngly1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K3480605 3 x 1.0 ug
EUR 451.2

Ngly1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)

K6240606 1.0 ug DNA
EUR 200.4

Ngly1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

K6240607 1.0 ug DNA
EUR 200.4

Ngly1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

K6240608 1.0 ug DNA
EUR 200.4

NGLY1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K1424906 1.0 ug DNA
EUR 200.4

NGLY1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K1424907 1.0 ug DNA
EUR 200.4

NGLY1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K1424908 1.0 ug DNA
EUR 200.4

Ngly1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K3480606 1.0 ug DNA
EUR 200.4

Ngly1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K3480607 1.0 ug DNA
EUR 200.4

Ngly1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K3480608 1.0 ug DNA
EUR 200.4

NGLY1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV690134 1.0 ug DNA
EUR 818.4

NGLY1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV690135 1.0 ug DNA
EUR 888

NGLY1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV690136 1.0 ug DNA
EUR 888

Peptide-N(4)-(N-Acetyl-Beta-Glucosaminyl)asparagine Amidase (NGLY1) Antibody

abx122116-100ug 100 ug
EUR 469.2

Rat Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1) ELISA Kit

abx391708-96tests 96 tests
EUR 1093.2

Mouse Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1) ELISA Kit

abx390048-96tests 96 tests
EUR 1093.2

(S)-N-Glycidylphthalimide

abx184516-25g 25 g
EUR 276

Human N-glycosylase/DNA lyase (OGG1)

1-CSB-YP016313HU
  • EUR 604.80
  • EUR 318.00
  • EUR 2198.40
  • EUR 915.60
  • EUR 1459.20
  • EUR 400.80
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human N-glycosylase/DNA lyase(OGG1) expressed in Yeast

Human N-glycosylase/DNA lyase (OGG1)

1-CSB-EP016313HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human N-glycosylase/DNA lyase(OGG1) expressed in E.coli

Human N-glycosylase/DNA lyase (OGG1)

1-CSB-EP016313HUa2
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human N-glycosylase/DNA lyase(OGG1) expressed in E.coli

N-Glycolylneuraminic acid

GC2820-10MG 10 mg
EUR 151.2

N-Glycolylneuraminic acid

GC2820-10 10
EUR 95

Rat N-glycosylase/DNA lyase (OGG1) ELISA Kit

abx516918-96tests 96 tests
EUR 801.6

Rat OGG1(N-glycosylase/DNA lyase) ELISA Kit

ER1877 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.094 ng/ml

Rat Ogg1/ N-glycosylase/DNA lyase ELISA Kit

E0712Ra 1 Kit
EUR 685.2

ELISA kit for Human N-glycosylase/DNA lyase

EK3399 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human N-glycosylase/DNA lyase in samples from serum, plasma, tissue homogenates and other biological fluids.

Human N-glycosylase/DNA lyase (OGG1) ELISA Kit

abx250893-96tests 96 tests
EUR 801.6

Mouse N-glycosylase/DNA lyase (OGG1) ELISA Kit

abx575710-96tests 96 tests
EUR 801.6

Mouse N-glycosylase/DNA lyase (OGG1) ELISA kit

CSB-EL016313MO-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse N-glycosylase/DNA lyase (OGG1) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse N-glycosylase/DNA lyase (OGG1) ELISA kit

1-CSB-EL016313MO
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse N-glycosylase/DNA lyase (OGG1) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human OGG1(N-glycosylase/DNA lyase) ELISA Kit

EH1601 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human OGG1/ N-glycosylase/DNA lyase ELISA Kit

E1823Hu 1 Kit
EUR 685.2

Mouse Ogg1/ N-glycosylase/DNA lyase ELISA Kit

E1076Mo 1 Kit
EUR 685.2

N-glycolyted Muramyldipeptide

VAdv-Ly0032 5 mg
EUR 2557.2
Description: N-glycolyted muramyldipeptide, a NOD2 agonist vaccine adjuvant.

N-Glycosylase Recombinant Protein

91-111 0.05 mg
EUR 651.3
Description: Human N-Glycosylase/DNA Lyase is a DNA repair enzyme, which incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. DGG1 has a beta -lyase activity that nicks DNA 3’ to the lesion.

Recombinant Human N-Glycosylase/OGG1 (N-GST)

C128-10ug 10ug
EUR 187.2
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.

Recombinant Human N-Glycosylase/OGG1 (N-GST)

C128-1mg 1mg
EUR 2739.6
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.

Recombinant Human N-Glycosylase/OGG1 (N-GST)

C128-500ug 500ug
EUR 1935.6
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.

Recombinant Human N-Glycosylase/OGG1 (N-GST)

C128-50ug 50ug
EUR 442.8
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.

Anti-NGLY1 antibody

STJ118323 100 µl
EUR 332.4

Recombinant Human N-glycosylase/ DNA lyase Protein, His, E.coli-1mg

QP6448-ec-1mg 1mg
EUR 1958.4

Recombinant Human N-glycosylase/ DNA lyase Protein, His, E.coli-10ug

QP6448-ec-10ug 10ug
EUR 240

Recombinant Human N-glycosylase/ DNA lyase Protein, His, E.coli-50ug

QP6448-ec-50ug 50ug
EUR 315.6

Recombinant Human N-glycosylase/ DNA lyase Protein, His, Yeast-1mg

QP6448-ye-1mg 1mg
EUR 2763.6

Recombinant Human N-glycosylase/ DNA lyase Protein, His, E.coli-100ug

QP6448-ec-100ug 100ug
EUR 489.6

Recombinant Human N-glycosylase/ DNA lyase Protein, His, E.coli-200ug

QP6448-ec-200ug 200ug
EUR 760.8

Recombinant Human N-glycosylase/ DNA lyase Protein, His, E.coli-500ug

QP6448-ec-500ug 500ug
EUR 1272

Recombinant Human N-glycosylase/ DNA lyase Protein, His, Yeast-10ug

QP6448-ye-10ug 10ug
EUR 326.4

Recombinant Human N-glycosylase/ DNA lyase Protein, His, Yeast-50ug

QP6448-ye-50ug 50ug
EUR 424.8

Recombinant Human N-glycosylase/ DNA lyase Protein, His, Yeast-100ug

QP6448-ye-100ug 100ug
EUR 685.2

Recombinant Human N-glycosylase/ DNA lyase Protein, His, Yeast-200ug

QP6448-ye-200ug 200ug
EUR 1077.6

Recombinant Human N-glycosylase/ DNA lyase Protein, His, Yeast-500ug

QP6448-ye-500ug 500ug
EUR 1806

Thermolabile UNG (Uracil N-Glycosylase)Prevention of carry-over contaminations** shipped ice packs - must be shipped via overnight service

M-PCR-353 200 units
EUR 186
Description: Thermolabile UNG (Uracil N-Glycosylase)Prevention of carry-over contaminations** shipped ice packs - must be shipped via overnight service

([15N]Gly)-Glutathione

H-4586.0025 25.0mg
EUR 1009.2
Description: Sum Formula: C20H3215N2N4O12S2; CAS# [1926163-36-1]

([15N]Gly)-Glutathione

H-4586.0100 100.0mg
EUR 2953.2
Description: Sum Formula: C20H3215N2N4O12S2; CAS# [1926163-36-1]

([15N]Gly)-Glutathione (reduced)

H-4584.0025 25.0mg
EUR 1341.6
Description: Sum Formula: C10H1715NN2O6S; CAS# [320374-87-6]

([15N]Gly)-Glutathione (reduced)

H-4584.0100 100.0mg
EUR 3952.8
Description: Sum Formula: C10H1715NN2O6S; CAS# [320374-87-6]

Human CellExp? LRRC4 /NGL-2, human recombinant

7461-10 each
EUR 326.4

Human CellExp? LRRC4 /NGL-2, human recombinant

7461-50 each
EUR 861.6

NGL 2 Recombinant Protein

96-523 0.1 mg
EUR 651.3
Description: LRRC4 (Leu-rich repeat/LRR-containing glycoprotein 4), LRRC4B and LRRC4C are post-synaptic adhesion molecules of the LRR protein family that induce excitatory synapse formation. LRRC4 is also known as Brain tumor-associated protein BAG, Netrin-G2 ligand (NGL-2), Nasopharyngeal carcinoma-associated gene 14 protein (NAG14), which contains 1 Ig-like (immunoglobulin-like) domain and 9 LRR (leucine-rich) repeats, 1 LRRCT domain, 1 LRRNT domain. LRRC4 / NGL-2 specifically expressed in brain. LRRC4 / NGL-2 regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. LRRC4 / NGL-2 organize the lamina/pathway-specific differentiation of dendrites. LRRC4 / NGL-2 plays a important role for auditory synaptic responses and involved in the suppression of glioma.

N1-Glutathionyl-spermidine disulfide

H-1126.0005 5.0mg
EUR 544.8
Description: Sum Formula: C34H66N12O10S2; CAS# [108081-77-2]

N1-Glutathionyl-spermidine disulfide

H-1126.0025 25.0mg
EUR 2067.6
Description: Sum Formula: C34H66N12O10S2; CAS# [108081-77-2]

RESULTSPrecise information of liver anatomy and its variations is paramount for fulfillment in ALPPS. Technical modifications, primarily much less invasive approaches like partial, mini- or laparoscopic ALPPS, largely aiming at minimizing the extensiveness of the first-stage process, are related to improved security. In fibrotic/cirrhotic livers the diploma of future liver remnant hypertrophy after ALPPS seems some lower than that in noncirrhotic.

Recent knowledge from the solely potential randomized managed trial confirmed vital larger resection charges in ALPPS with comparable peri-operative morbidity and mortality charges in contrast with standard 2-stage hepatectomy together with portal vein embolization. ALPPS is efficient reliably even after failure of portal vein embolization.

CONCLUSIONSAlthough ALPPS is now a longtime 2-stage hepatectomy further knowledge are warranted to additional refine indication and technical facets. Long-term oncological end result outcomes are wanted to set up the place of ALPPS in sufferers with initially nonresectable liver tumors.

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