BACKGROUNDThe Semantically Annotated Media (SAM) undertaking goals to supply a versatile platform for looking, searching, and indexing medical studying objects (MLOs) based mostly on a semantic community derived from established classification programs.
Primarily, SAM helps the Aachen emedia expertise lab, however SAM is prepared for indexing distributed content material and the Simple Knowledge Organizing System normal gives a means for simply upgrading and even exchanging SAM’s semantic community. There is a lack of analysis addressing the usability of MLO indexes or search portals like SAM and the consumer habits with such platforms.
OBJECTIVEThe objective of this research was to evaluate the usability of SAM by investigating attribute consumer habits of medical college students accessing MLOs through SAM.METHODSIn this research, we selected a mixed-methods strategy.
Lean usability testing was mixed with usability inspection by having the members full 4 typical utilization eventualities earlier than filling out a questionnaire. The questionnaire was based mostly on the IsoMetrics usability stock. Direct consumer interplay with SAM (mouse clicks and pages accessed) was logged.
RESULTSThe research analyzed the everyday utilization patterns and habits of college students utilizing a semantic community for accessing MLOs. Four eventualities capturing traits of typical duties to be solved through the use of SAM yielded excessive rankings of usability gadgets and confirmed good outcomes regarding the consistency of indexing by totally different customers.
Long-tail phenomena emerge as they’re typical for a collaborative Web 2.zero platform. Suitable however nonetheless not often used key phrases had been assigned to MLOs by some customers.
CONCLUSIONSIt is feasible to develop a Web-based instrument with excessive usability and acceptance for indexing and retrieval of MLOs. SAM may be utilized to indexing multicentered repositories of MLOs collaboratively.
Description: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
Description: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
Description: Neutrophil elastase, also called Elane, is a serine protease of neutrophil and monocyte granules. Its key physiologic role is in innate host defense, but it can also participate in tissue remodeling and possesses secretagogue actions important to local inflammatory responses. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.
Description: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. [RefSeq]
Description: Neutrophil elastase inhibitor 5 (compound 29) is a dual inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3) with IC50 values of 4.91 μM and 20.69 μM, respectively. Neutrophil elastase inhibitor 5 can be used in the study of neutrophil inflammatory diseases[1].
Semantic Indexing of Medical Learning Objects: Medical Students’ Usage of a Semantic Network.
Efficacy of peritoneovenous shunt for treating tolvaptan-resistant refractory ascites in a cirrhotic affected person with portal vein thrombosis: A case report.
Peritoneovenous shunt is often used for the remedy of refractory ascites. However, its efficacy in treating tolvaptan-resistant refractory ascites has not been reported to this point. In addition, the influence of peritoneovenous shunt on the prognosis of cirrhotic sufferers stays controversial. In the current report, a case of tolvaptan-resistant refractory ascites related to liver cirrhosis and portal vein thrombosis is described.
The male affected person was identified with hepatitis C virus-related liver cirrhosis on the age of 51 years. At the age of 56 years, the affected person developed portal vein thrombosis, ensuing within the improvement of refractory ascites.
Since the ascites was proof against remedy with a low-sodium weight loss plan and diuretics resembling tolvaptan, a peritoneovenous shunt was implanted upon acquiring consent. The shunt instantly elevated the urine quantity, and the ascites was markedly decreased. The affected person’s physique weight decreased from 62.7 to 57.1 kg in 2 days, and his ascites symptom stock-7 rating decreased from 23 to zero factors in 31 days.
Although the affected person succumbed to sepsis on day 486 following the shunt implant, his actions of day by day residing had been preserved till eight days previous to mortality. Thus, the current case helps the efficacy of peritoneovenous shunt for the remedy of tolvaptan-resistant refractory ascites related to liver cirrhosis and portal vein thrombosis.
Furthermore, the current case means that peritoneovenous shunt could lengthen the survival of cirrhotic patents with refractory ascites.
