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Peak protein from the mutant strain B.1.617.2, also commonly known as the “Delta Variant”. It is a full-length protein, which is active in its native trimeric form, which is stabilized in LMNG detergent. All viruses undergo rapid mutations and adapt quickly to the countermeasures that the immune system creates against them. The SARS-CoV-2 of the … Read more
CYP2C9 is a phase I drug-metabolizing cytochrome P450 (CYP450) enzyme isoform that plays a major role in the oxidation of both xenobiotic and endogenous compounds. Gray et al. identified CYP2C9 as one of several CYP2C genes clustered in a 500 kb region on chromosome 10q24. The cluster comprises four genes arranged in the order CYP2C8-CYP2C9-CYP2C19-CYP2C18. Several studies identified a single … Read more