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   COLLABORATIVE PROJECTS

Interbio aims at promoting interdisciplinary and interregional research in the field of health & life sciences. Interbio can provide mobility support (transport & accommodation) for scientists interested in setting up collaborative research projects.
For more information, please contact your local WP3 coordinator.

TGFbeta signaling in cardiovascular alterations associated with the Marfan syndrome

Partner A Member : Barcelona
Name of principal investigator : GUSTAVO
FirstName : Egea
E-mail : gegea@ub.edu
Position : Staff
Affiliation Name : University of Barcelona school of medicine
Road : C Casanova 143
Postbox :
Town : Barcelona
Country : Spain
Partner B Member : Bordeaux
Name of principal investigator : GENOT
FirstName : Elisabeth
E-mail : e.genot@iecb.u-bordeaux.fr
Position : Staff
Affiliation Name : IECB
Road : 2n Rue Robert Escarpit
Postbox :
Town : Pessac
Country : France
Request for financial support 1 scientist for 5 days (Partner A to Partner B)
Perspectives of extension of this common project to a more ambitious proposal to be submitted to funding agencies : Short term
Added value of the cooperation : application of fundamental research for clinical settings (Marfan syndrome)

Summary of the proposal : the purpose of this exchange is to learn the innovative cell culture methodology of different parts of aorta (ascending, arch, and descending) developed by the host group (Elisabeth Genot). Her laboratory is interested in the role of TGF-beta in the formation of podosomes in endothelial cells. My laboratory is interested in the trafficking of TGF-beta receptors, and associated signaling components, in vascular smooth muscle cells and fibroblasts in patients with Marfan syndrome. This is a rare connective tissue-associated genetic disorder caused by mutations in the fibrillin-1 gene. The mutated protein leads to a fragmentation of the elastin network of the tunica media as a result of excessive degradation by matrix metalloproteases. A second mechanism by which the fibrillin mutation causes aortic disease in Marfan syndrome involves TGF-beta. There is evidence that mutant fibrillin 1 has a low affinity binding site for latent TGF-beta (its inactive form) and sequesters the cytokine (making it unaccessible for cells). In its absence and with the action of metalloproteases, levels of active TGF-beta rise and this leads to an aberrant cellular behaviour (of different kinds) amongst which an unusual configuration of the actin cytoskeleton. The main final clinical consequence of hyper-TGF-beta activity is the formation of aneurysm and rupture of the ascending aorta. Therefore, Marfan syndrome is an excellent translational medicine model for the study aneurysms, which result from alterations in the TGFbeta-associated signaling and the disassembly of the extracellular matrix. There is an animal model of this disorder (Marfan mice), which was generated by the laboratory of Hal Dietz (Baltimore, USA). This model is currently available in the laboratory of Dr Genot. The initial work plan is to visit the her laboratory and to learn to apply in my research her innovative method to culture endothelial cells from explants of different parts of aorta from Marfan mice.

Dr. Elisabeth Génot and myself had the opportunity to meet for a first time in a recent meeting hold in Madrid (Sept. 18-21 September; Podosomes, Invadopodia and Focal Adhesions in Physiology and Pathology) and we realized of our common interest in Marfan disease and of our complementarity aims in research.

Antonio PINEDA-LUCENA, Valencia
Claudio GOMES, Lisboa
Using metabonomics to understand fatty acid oxidation disease View proposal
Miriam ROYO EXPOSITO, Barcelona
Ivan HUC, Bordeaux
Exploring delta-aromatic carboxamide foldamers and alpha-peptides compatibility View proposal
Salvador VENTURA ZAMORA, Barcelona
Ana VARELA COELHO, Lisboa
GT4.- Proteomic analysis of cellular responses to protein-aggregation-mediated stress View proposal
Olivier GADAL, Toulouse
Marc MARTI-RENOM, Valencia
Integrating probabilistic maps and 3C-based data for determining high-resolution 3D structure of yeast chromosomes View proposal
Yann ASTIER, Lisboa
Josep SAMITIER, Barcelona
Nanochannels for single molecule studies View proposal
Jacqueline GRIMA PETTENATI, Toulouse
Jorge PINTO PAIVA, Lisboa
The MicroRNAs in Eucalyptus tension wood world View proposal
Royo BEATRIZ , Lisboa
Gómez MONTSERRAT, Toulouse
Molybdenum complexes containing chiral oxazoline ligands: coordination and catalysis View proposal
Fernando ROCH, Toulouse
Elio SUCENA, Lisboa
Studying functional diversification and evolution of regulatory sequences after a gene duplication event View proposal
Gilles GUICHARD, Bordeaux
Fernando ALBERICIO, Barcelona
High-Throughput Screening of one-bead/one-compound (OBOC) foldamer libraries against protein targets View proposal
Bruno BRUNO VICTOR, Lisboa
Xavier XAVIER DAURA, Barcelona
Molecular Simulations of Hemagglutinin from Influenza virus View proposal
Bernard MONSARRAT, Toulouse
Lucas DEL CASTILLO AGUDO, Valencia
WG1 Comparative proteome analysis of C. albicans strains SC5314 and CAI4 View proposal
Peter FALLER, Toulouse
Claudio GOMES, Lisboa
Structural and functional aspects of the Cu/Fe-amyloid-beta complex View proposal
Egea GUSTAVO, Barcelona
Elisabeth GENOT, Bordeaux
TGFbeta signaling in cardiovascular alterations associated with the Marfan syndrome View proposal
Cecilia ARRAIANO, Lisboa
Muriel COCAIGN-BOUSQUET, Toulouse
Stabilome E coli View proposal
Muñoz-almagro CARMEN , Barcelona
Sa-leao RAQUEL, Lisboa
Invasiveness of pneumococcal serotypes and clones circulating in Catalonia during heptavalente conjugate vaccine period View proposal
Olga IRANZO, Lisboa
Rafel PROHENS, Barcelona
Study of the influence of peptide flexibility on metal ion coordination properties View proposal
Rita ABRANCHES, Lisboa
José maría SEGUÍ, Valencia
Investigating the subcellular trafficking of human recombinant proteins expressed in plants View proposal
Francesc PALAU, Valencia
Cláudio GOMES, Lisboa
Evaluation of mitochondrial beta-oxidation flavoenzymes in a cellular model of Friedreich ataxia View proposal
Jean-jacques TOULMÉ, Bordeaux
Claudio GOMES, Lisboa
Studies on human S100 protein-aptamer complexes View proposal
Justine BERTRAND-MICHEL, Toulouse
Gemma FABRIÀS, Barcelona
WP4 Sphingolipidomic technical exchange View proposal
Célia ROMÃO, Lisboa
Jordi juanhuix GIBERT, Barcelona
Introduction to the MX XALOC BL13 Beamline at ALBA View proposal
   

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