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   COLLABORATIVE PROJECTS

Interbio aims at promoting interdisciplinary and interregional research in the field of health & life sciences. Interbio can provide mobility support (transport & accommodation) for scientists interested in setting up collaborative research projects.
For more information, please contact your local WP3 coordinator.

Studies on human S100 protein-aptamer complexes

Partner A Member : Bordeaux
Name of principal investigator : TOULMÉ
FirstName : Jean-jacques
E-mail : jean-jacques.toulme@inserm.fr
Position : Staff
Affiliation Name : IECB
Road : 2 rue R. Escarpit
Postbox :
Town : Pessac
Country : France
Partner B Member : Lisboa
Name of principal investigator : GOMES
FirstName : Claudio
E-mail : gomes@itqb.unl.pt
Position : Staff
Affiliation Name : ITQB
Road : Av Republica
Postbox :
Town : Oeiras
Country : Portugal
Request for financial support 1 scientist for 15 days (Partner B to Partner A)
Perspectives of extension of this common project to a more ambitious proposal to be submitted to funding agencies : Short term
Added value of the cooperation : ITQB has the proteins, IECB the aptamer.

Summary of the proposal : The S100 proteins are a multi-gene calcium-binding family comprising 20 known human members each coded by a separate gene. They are small, acidic proteins found exclusively in vertebrates. The expression of S100 proteins has been demonstrated in a diverse spectrum of tissues. S100 proteins have a broad range of intracellular and extracellular functions, including include regulation of protein phosphorylation and enzyme activity, calcium homeostasis, regulation of cytoskeletal components and regulation of transcriptional factors. Some members of the family act as leukocyte chemoattractants, macrophage activators and modulators of cell proliferation. S100 proteins are associated with a variety of pathologies such as inflammation and cardiomyopathies, and gradually their role in carcinogenesis is unraveled.

In the frame of a previous project aiming at the identification of aptamers to membrane proteins the IECB team raised aptamers that proteomics analysis tentatively identified as a S100 ligands. The binding properties and the specificity of these aptamers were not determined. It turns out that the ITQB team develops investigations on this class of proteins. This collaborative project aims firstly at characterizing the S100-aptamer complexes. Surface Plasmon Resonance analysis will be carried out on the IECB platform in order to evaluate the equilibrium constant of the complexes. Various S100 proteins will be assayed. Once  characterized these aptamers could be used by the ITQB team for structure/function studies and by the IECB team for biotechnological developments (targeting, imaging).

Antonio PINEDA-LUCENA, Valencia
Claudio GOMES, Lisboa
Using metabonomics to understand fatty acid oxidation disease View proposal
Miriam ROYO EXPOSITO, Barcelona
Ivan HUC, Bordeaux
Exploring delta-aromatic carboxamide foldamers and alpha-peptides compatibility View proposal
Salvador VENTURA ZAMORA, Barcelona
Ana VARELA COELHO, Lisboa
GT4.- Proteomic analysis of cellular responses to protein-aggregation-mediated stress View proposal
Olivier GADAL, Toulouse
Marc MARTI-RENOM, Valencia
Integrating probabilistic maps and 3C-based data for determining high-resolution 3D structure of yeast chromosomes View proposal
Yann ASTIER, Lisboa
Josep SAMITIER, Barcelona
Nanochannels for single molecule studies View proposal
Jacqueline GRIMA PETTENATI, Toulouse
Jorge PINTO PAIVA, Lisboa
The MicroRNAs in Eucalyptus tension wood world View proposal
Royo BEATRIZ , Lisboa
Gómez MONTSERRAT, Toulouse
Molybdenum complexes containing chiral oxazoline ligands: coordination and catalysis View proposal
Fernando ROCH, Toulouse
Elio SUCENA, Lisboa
Studying functional diversification and evolution of regulatory sequences after a gene duplication event View proposal
Gilles GUICHARD, Bordeaux
Fernando ALBERICIO, Barcelona
High-Throughput Screening of one-bead/one-compound (OBOC) foldamer libraries against protein targets View proposal
Bruno BRUNO VICTOR, Lisboa
Xavier XAVIER DAURA, Barcelona
Molecular Simulations of Hemagglutinin from Influenza virus View proposal
Bernard MONSARRAT, Toulouse
Lucas DEL CASTILLO AGUDO, Valencia
WG1 Comparative proteome analysis of C. albicans strains SC5314 and CAI4 View proposal
Peter FALLER, Toulouse
Claudio GOMES, Lisboa
Structural and functional aspects of the Cu/Fe-amyloid-beta complex View proposal
Egea GUSTAVO, Barcelona
Elisabeth GENOT, Bordeaux
TGFbeta signaling in cardiovascular alterations associated with the Marfan syndrome View proposal
Cecilia ARRAIANO, Lisboa
Muriel COCAIGN-BOUSQUET, Toulouse
Stabilome E coli View proposal
Muñoz-almagro CARMEN , Barcelona
Sa-leao RAQUEL, Lisboa
Invasiveness of pneumococcal serotypes and clones circulating in Catalonia during heptavalente conjugate vaccine period View proposal
Olga IRANZO, Lisboa
Rafel PROHENS, Barcelona
Study of the influence of peptide flexibility on metal ion coordination properties View proposal
Rita ABRANCHES, Lisboa
José maría SEGUÍ, Valencia
Investigating the subcellular trafficking of human recombinant proteins expressed in plants View proposal
Francesc PALAU, Valencia
Cláudio GOMES, Lisboa
Evaluation of mitochondrial beta-oxidation flavoenzymes in a cellular model of Friedreich ataxia View proposal
Jean-jacques TOULMÉ, Bordeaux
Claudio GOMES, Lisboa
Studies on human S100 protein-aptamer complexes View proposal
Justine BERTRAND-MICHEL, Toulouse
Gemma FABRIÀS, Barcelona
WP4 Sphingolipidomic technical exchange View proposal
Célia ROMÃO, Lisboa
Jordi juanhuix GIBERT, Barcelona
Introduction to the MX XALOC BL13 Beamline at ALBA View proposal
   

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