Interbio aims at promoting interdisciplinary and interregional research in the field of health & life sciences. Interbio can provide mobility support (transport & accommodation) for scientists interested in setting up collaborative research projects. For more information, please contact your local WP3 coordinator.
Study of the influence of peptide flexibility on metal ion coordination properties
Perspectives of extension of this common project to a more ambitious proposal to be submitted to funding agencies : Short term Added value of the cooperation : Exchange of expertise
Summary of the proposal :
The flexibility of the peptidic scaffold can play a crucial role in determining the formation and geometry of different metal ion complexes in solution and thus, of their properties. Recent results in our group show how peptides with similar amino acid sequences but different degrees of flexibility form different Cu(II) complexes. The aim of this short visit is to explore the use of Isothermal Titration Calorimetry to study and determine the enthalpic (ΔH) and entropic (ΔS) components associated to the Cu(II) binding to these different peptides. The group of Dr. Rafel Prohenshas strong expertise in the application of this technique to study metal binding, both in chemical and biological systems. The results obtained will give us an important insight into the impact of the peptidic scaffold flexibility in metal coordination.
Antonio PINEDA-LUCENA, Valencia Claudio GOMES, Lisboa
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