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Post-doc position: the role of prion folds in signal transduction in fungi
28 november 2011-12 january 2012

Post-doc position: the role of prion folds in signal transduction in fungi

A two-year post-doc position is available at the Institut de Biochimie et de Génétique Cellulaire, CNRS, Bordeaux, France. This position involves using biochemical, microscopic and genetic approaches to dissect the functional and structural interplay between signal transducing NTPases of the STAND superfamily and fungal prion proteins. The project is based on the characterization of a newly identified partner of the HET-s prion protein of the filamentous fungus Podospora anserina as well as the analysis of novel fungal prions and prion forming domains and their role in fungal biology.

Background information can be found for instance in:

  • Saupe SJ (2011) The [Het-s] prion of Podospora anserina and its role in heterokaryon incompatibility. Semin Cell Dev Biol 22: 460-468
  • Benkemoun L, Ness F, Sabate R, Ceschin J, Breton A, Clave C, Saupe SJ (2011) Two structurally similar fungal prions efficiently cross-seed in vivo but form distinct polymers when coexpressed. Mol Microbiol Nov 3. doi: 10.1111/j.1365-2958.2011.07893.x
  • Greenwald J, Buhtz C, Ritter C, Kwiatkowski W, Choe S, Maddelein ML, Ness F, Cescau S, Soragni A, Leitz D, Saupe SJ, Riek R (2010) The mechanism of prion inhibition by HET-S. Mol Cell 38: 889-899
  • Mathur V, Seuring C, Riek R, Saupe SJ, Liebman SW (2011) Localization of HET-S to the cell periphery, and not to [Het-s] aggregates, is associated with [Het-s]-HET-S toxicity. Mol Cell Biol, Oct 28.
  • Paoletti M, Saupe SJ (2009) Fungal incompatibility: evolutionary origin in pathogen defense? Bioessays 31: 1201-1210

Candidates should hold a Ph.D. in biochemistry, genetics, microbiology or molecular biology. Previous experience in microbiology, fungal biology and protein biochemistry could be of advantage.

Applicants should submit a CV and a summary of research experience via email to Sven Saupe at sven.saupe@ibgc.u-bordeaux2.fr or by mail to:

Sven J. Saupe
1 rue Camille St Saens
33077 Bordeaux cedex

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