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Interbio aims at fostering innovation in health & life sciences by promoting technology transfer and public/private partnerships. Please find below a list of technology transfer offers posted by members of Interbio.
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Gastro-intestinal Dynamic Simulator (GDS)
Title : Gastro-intestinal Dynamic Simulator (GDS)
Contact Email : ana.barbera@fivec.org
Abstract : A research centre has developed an artif icial in vitro digestive system. This model simulates the ow n conditions of in vivo human gastrointestinal tract allowing a good understanding of the food digestion matrix and its nutrient release during gastrointestinal passage. The centre seeks partners for a technical cooperation to assess the functionalities from functional food and ingredients.
Description :

The novelty Gastro-intestinal Dynamic Simulator (GDS) model is a system able to simulate human gastrointestinal tract conditions w hat makes possible to better understand the food digestion and nutrients absorption.
This model comprises 4 glass compartments simulating stomach and small intestine, which are connected by computer-controlled valve pumps. The main variables of digestion, such as pH, body temperature, peristaltic mixing and transit, speed of gastric emptying; gastro-intestinal secretions and absorption of small molecules can be completely regulated by a panel PC.
Moreover, sampling is possible at various times during the digestive process, enabling gathering of information in real time to better understanding of the digestive process.
As a result the system enables research on nutritional and functional aspects on single compounds as w ell as in complete meal matrices during passage through the upper gastrointestinal tract under strictly controlled human conditions.
Innovative Aspects:
The Gastro-intestinal Dynamic Simulator (GDS) enables research on nutritional and functional aspects on single or combined compounds as well as in complete meal matrices during passage through the upper gastro-intestinal tract under strictly controlled human conditions. This kind of evaluations could be carried out through other methods such as in vivo or in vitro assays which took more time and do not provide the level of details that is provided by the GDS.
A w ide range of physic-chemical properties of formulations can be investigated with this model, including coating stability, solubility, release prof ile, nutrient interactions, resistance against digestive conditions and availability for absorption. The information given by the model allows companies to make better decisions on the development and improvement of new functional products. Moreover, the results facilitate the def inition of an optimal set-up for possible clinical

State of Development and IPR : patent applied
Intended collaboration : joint R&D
Application or research field : Dynamic simulation
Medicaments (drugs)
Key words technology :

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Use of seconeolitsine and N-metyl-seconeolitsine for fabrication of antimicrobial drugs. The invention refers to two phenanthrene alkaloids: seconeolitsine and N-methyl-seconeolitsine for the manufacture of drugs, preferably for the treatment of diseases caused by the Gram-positive bacteria Streptococcus pneumoniae. View information
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Phosphorus-based dendrimers for human immuno-modulation Dendrimers are a class of highly branched “tree-like” polymers. Due to their sequential process of synthesis, they are characterized by perfectly defined structure and molecular weight. As their multivalency enables polyvalent interactions with cellular and/or molecular targets, they received tremendous attention along the two past decades regarding their uses in biology: drug delivery, biological imaging and tissue engineering. They are now part in their own right of the nanobiology and nanomedicine landscape. Among dendrimers, phosphorus-containing dendrimers capped with phosphonate end groups display unprecedented immunological properties towards cells of the human immune system. In particular, we have reported that an azabisphosphonate-capped dendrimer activates anti-inflammatory and immunosuppressive responses of the human immune system. These properties have been confirmed in vivo in a mouse model of Rheumatoid Arthritis. View information
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Gastro-intestinal Dynamic Simulator (GDS) A research centre has developed an artif icial in vitro digestive system. This model simulates the ow n conditions of in vivo human gastrointestinal tract allowing a good understanding of the food digestion matrix and its nutrient release during gastrointestinal passage. The centre seeks partners for a technical cooperation to assess the functionalities from functional food and ingredients. View information
Minigenome to cure HCV (Technology Offer) This invention concerns a suicide vector in the form of chimeric genomic RNA (negative strand). The negative single-strand RNA molecule is non coding. So, the sole replication complex of the virus can manage to transform it into a positive strand. The latter can then be traduced into a pathogenic compound which can destroy the contaminating virus. The infected hepatocyte returns by the way to a healthy state. View information
New compounds with anti-herpes activity (Technology Offer) This invention concerns new family of C3-arylated-3-deazauridine with potent anti-HSV activities and negligible cytotoxicity against various cell lines. In the pool of the already tested compounds, two molecules showed enhanced activities (close to the one of the reference acyclovir). View information
Calcemia and Response to Anticancer Drugs (Technology Offer) This invention is based on the original discovery that intracellular calcium ([Ca2+]i) negatively regulates the apoptotic signalling activated by Death Receptor engagement (Fas and DR4/DR5) (submitted to EMBO J). A decrease in [Ca2+]i results in a potentiation of the apoptotic effects of FasL, Rituximab and Trail killer, whereas an increase inhibits them. View information
Device for stimulating living tissues by micro electrodes (Technology Offer) Here, we propose a new electrode configuration that improves the focality of electrical stimulation without the need to consider multipolar electrodes. In this configuration, we introduce a ground surface surrounding all the electrodes of the array. Stimulations are delivered between each electrode of the array and the ground surface. Using this configuration, stimulation is all the more focal that the surface conductance of the ground surface is high. View information
Bio-microelectronic insulin demand sensor (Technology Offer) To precisely measure the demand in insulin and not only glycemia, we have for the first time used recordings on microelectrode arrays of electrical signals, the frequency of action potentials. These signals provide the first integrative read-out at the cellular level of all nutrients, sugars and hormones. We are able to detect online the electrical activity testifying for the insulin need. View information
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