Home
About Interbio
Find an Interbio partner
Find a technology platform
Find a technology transfer offer
Collaborative research projects
Upcoming events
Interbio news
Funding opportunities
Job opportunities
Members' highlights
Useful links
Contacts
Interbio Newsletter
Sign up and create your Interbio profile
ENTER INTERBIO
E-mail
Password

Forgotten your password ?


   MEMBERS' HIGHLIGHTS

Intelligent nanoparticles fight against cancer
11 october 2011-14 march 2012

Intelligent nanoparticles fight against cancer

Novel intelligent pharmaceutical form fights against cancer

Researchers of the Institute of Chemical Technology (ITQ), a joint centre of the Polytechnic University of Valencia and the Spanish National Research Council, presented recently at the 5th FEZA Conference the latest scientific achievements in the development of novel intelligent pharmaceutical forms, based in mesoporous silica nanoparticles, for their application in cancer treatment.

This novel therapeutic platform is made of small mesoporous silica nanoparticles, in the range of nanometers, which surface is functionalized with organic groups, thus giving an organic-inorganic hybrid material. In addition, the drug (camptothecin) is linked to such organic groups through a chemical bond sensitive to intracellular enzymes. This system enables drug and mesoporous material to enter the body and selectively accumulate in tumor cells by means of a enhanced permeability retention (EPR) mechanism. Within the cell, the activity of specific enzymes (carboxylases) allows for controlled and continuous release of camptothecin, provoking cell death by means of a topoisomerase-I inhibition mechanism. In this way, higher efficiency than in previous therapy is ensured (based in structural derivatives of camptothecin, less active and with very short plasma clearance time), as well as total lack of secondary effects in other tissues due to the cytotoxic activity of camptothecin.

Currently, ITQ researchers are using this novel system at the lab scale on mice (human colorectal xenografts) and the results achieved, recently published in the Journal of Controlled Release, are very promising.

According to Pablo Botella, Tenured Scientist of the ITQ, “we are at the preclinical stage, working in collaboration with the CIBBIM-Nanomedicine group of Hospital Vall d’Hebron, in Barcelona”. In this sense, “it is imperative to improve the biodistribution and the pharmacokinetics of the pharmaceutical form. Moreover, this must be tested in more animal models and different types of tumor before considering human testing. Actually, it is difficult to set a period before we can conduct clinical trials, as a mid-term study has not been carried out yet (current treatments in xenografts are usually performed during one to three months). Hence, we do not expect to move to the clinical stage in less than two years. The main problems of administering nanoparticulated vehicles in the living bod are the poor biodistribution, basically due to severe hepatic accumulation, and the lack of long-term studies that confirm the non-toxic character of nanoparticles. However, the improvedstability of the pharmaceutical preparation in biological fluids, the introduction of targeting molecules to cancer cells and the development of toxicological studies showing lack of toxicity of materials, together with the complete elimination from the body after treatment will introduce a new generation of intelligent drugs able to perform their therapeutic activity with no secondary effects”.

 

Figure: Antitumor activity of silica-camptothecin nano-hybrids (SNP-CPT)

The first scheme shows the hybrid nature of the pharmaceutical form, with a nucleous made of  silica nanoparticles and an organic shell containing the therapeutic agent. The second image shows growth evolution of tumor HT-29.Fluc in athymic female mice (day 22 of treatment) by bioluminescence image. Left: the control was administered saline solution. Right: mouse received two injections per week of a SNP-CPT suspension in saline solution, corresponding to a 0.8 mg CPT/kg dose. Significant tumor recession and necrosis in the SNP-CPT treated mouse can be observed.

ITQ’s drug delivery group is multidisciplinary and includes chemists, pharmacists and biologists http://itq.webs.upv.es/

RSS Feed
28-30 may 2012 - 9th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice (Valencia)
5-12 april 2012 - A STREAK FLIM SYSTEM (Fluorescence Lifetime Imaging Microscopy) to study protein-protein interaction (Toulouse)
23-31 march 2012 - Novel strategies to fight tuberculosis (Valencia)
21-31 march 2012 - Editorial by Pr Ijsbrand Kramer, WP3 coordinator (Bordeaux)
12 march 2012 - A new chemistry for drug design - Researchers develop ampicilin-based ionic liquids (Lisbon)
12 march 2012 - Training opportunities in Lisbon technological platforms (Lisbon)
17-18 november 2011 - Technology Offers: Presentation of the best offers from Interbio Network (Valencia)
17-18 november 2011 - The sequencing revolution: experiences from the Centro Nacional de Análisis Genómico (CNAG) (Barcelona)
17-18 november 2011 - Toulouse TRI Imaging Platform : Multiscale imaging of living organisms (Toulouse)
17-18 november 2011 - Toulouse Integrated Screening Platform (PICT) : Ligand discovery
17-18 november 2011 - Valencian Biobank Network Service Platforms (Valencia)
17-18 november 2011 - Imaging living life: Confocal Microscopy Unit at SCSIE, Universitat de València (Valencia)
17-18 november 2011 - Animal Facilities and Operating Theaters at the CIPF (Valencia)
17-18 november 2011 - Centre de Recerca en Sanitat Animal (CReSA) (Barcelona)
17-18 november 2011 - Mass spectrometry expertise at ITQB (Lisbon)
17-18 november 2011 - Skills in Bioinformatics via training courses (Lisbon)
17-18 november 2011 - Supramolecular assemblies and nanotechnology at the Structural Biology Platform, IECB (Bordeaux)
17-18 november 2011 - Nanotech Structural Analysis : the NMR platform at IECB (Bordeaux)
17-18 november 2011 - New dendrimers for rheumatoid arthritis treatment
17-18 november 2011 - Magnetic nanoparticles for cancer treatment (Toulouse)
17-18 november 2011 - Trans-feruloyl-noradrenaline, A new powerful natural antioxidant (Valencia)
17-18 november 2011 - Use of the PEDF factor to induce stem-cell self-renewal (Valencia)
17-18 november 2011 - Polyglutamates (PGA) of low polydispersity (Valencia)
17-18 november 2011 - Dental implants surgical guides fabrication method (Barcelona)
17-18 november 2011 - Protein nanoparticles for the targeted delivery of therapeutic peptides and nucleic acids to colorec (Barcelona)
17-18 november 2011 - Two tech offers : Bio-microelectronic insulin demand sensor and Novaptech (Bordeaux)
2-4 november 2011 - Hands-on protein identification by mass spec: open registrations training course (Lisbon)
26-27 october 2011 - 4th International Pediatric Simulation Symposia and Workshop (IPSSW 2011) (Toulouse)
24-25 october 2011 - II International Biotech Meeting: Business and Innovation opportunities in Biotech, a 360º approach (Valencia)
19 october 2011-31 march 2012 - Novaptech: Aptamers as biotechnological tools for analysis, diagnostic and therapy (Bordeaux)
19 october-31 december 2011 - The longest oligourea foldamer: 4,3 nanometers (Bordeaux)
17-22 october 2011 - XVI National Congress of the Spanish Society of Medicinal Chemistry (Valencia)
14 october 2011-19 may 2012 - Valencia Microclusters. VLC-CAMPUS: Valencia, International Campus of Excellence (Valencia)
14 october-30 november 2011 - A new mechanism of defense against infections (Toulouse)
14 october 2011-29 february 2012 - The Biological NMR facility of the Institute of Pharmacology and Structural Biology (IPBS) (Toulouse)
14 october-31 december 2011 - “TULIP” laboratory of excellence in Toulouse (Toulouse)
14 october 2011 - To sporulate or not to sporulate? Negative feedback loop controls positive auto-regulation in bacter (Lisbon)
11 october 2011-14 march 2012 - Intelligent nanoparticles fight against cancer (Valencia)
4 october 2011-30 june 2012 - An Interbio success story: Nanopore Solutions (Lisbon)
18-21 september 2011 - Interbio Label: The XVIth National Meeting of the Spanish Society of Medicinal Chemistry at the CIPF (Valencia)
14-16 september 2011 - 3rd European Cancer Cluster Partnering (ECCP) event (Toulouse)
14-16 september 2011 - Workshop NBI Tech 2 Life (Toulouse)
1 september 2011-29 february 2012 - Editorial by Jean-Pierre Saintouil, Coordinator of Interbio WP5 (Toulouse)
11 july-22 june 2011 - The Barcelona – Toulouse Summer School on Medicines (SSM3) incorporates a new international partner (Barcelona)
3-7 july 2011 - XIX EuCheMS Conference on Organometallic Chemistry (Toulouse)
1 july 2011 - METATOUL: an Interbio breakfast for companies on July 1st (Toulouse)
14 june-31 august 2011 - Liquid and solid NMR ranging from 300 to 800 MHz at IECB (Bordeaux)
14-30 june 2011 - METATOUL : the Metabolomics and Fluxomics platform of Toulouse (Toulouse)
14 june-30 september 2011 - A hybrid bioelectronic sensor for drug and toxicity screening and diabetes therapy (Bordeaux)
14 june-31 august 2011 - A breakthrough in the design of molecular motors (Bordeaux)
19 may-31 august 2011 - Technology platforms and major research infrastructures in Catalonia (Barcelona)
19 may-31 august 2011 - Driving technology transfer (Barcelona)
13 may-21 october 2011 - Valencian Biobank La Fe: A success model of Biobanks for Biomedical Research (Valencia)
13 may-22 october 2011 - Researchers at Valencia Polytechnic University develop an online service for human brain study (Valencia)
13 may 2011 - Editorial by Prof. Miguel S. Teixeira, Coordinator of Interbio Lisbon (Lisbon)
13 may 2011 - IBET Viral Vector Platform (Lisbon)
11 may-31 august 2011 - A molecule from oak wood to fight osteoporosis (Bordeaux)
10 may 2011 - How bacteria trick each other in their math (Lisbon)
14-15 april 2011 - The third StatSeq workshop on “Statistical challenges on the 1000 € genome sequences in plants” (Toulouse)
21-25 march 2011 - MDA11 International Course on MASSIVE Data Analysis (Valencia)
17 march 2011 - Bordeaux RNA Club Seminar at IECB : guest speaker Ciaran Condon (Bordeaux)
11 march 2011 - Parallel Symposium : Innovative Approaches and Biomarkers in Parkinson Disease (Barcelona)
10 march 2011 - 4th edition of Barcelona Healthcare Investment Forum (Barcelona)
10-11 march 2011 - XIII International Course on Pediatric Neurology and Neuropsychology (Valencia)
9-13 march 2011 - 10th International Conference on Alzheimer's & Parkinson's Diseases (Barcelona)
4 march 2011 - 8th International Symposium on Advanced Ovarian Cancer: Optimal Theraphy Update (Valencia)
23 february-31 december 2011 - Feedback on Interbio cross-border research projects, by Antoni Homs Corbera (IBEC) (Barcelona)
22 february-31 may 2011 - Interbionews editorial by Alain-Michel Boudet, Director of the Interbio project (Toulouse)
22 february-31 may 2011 - IECB is developing a robotic device for crystallizing membrane proteins in mesophases (Bordeaux)
22 february-30 may 2011 - Pharmacological Screening: Identification of bioactive agents modulators of novel molecular targets (Valencia)
22 february-30 may 2011 - Artificial Pancreas: advances, challenges and opportunities (Valencia)
22 february-30 may 2011 - Labplayer: An innovative technology using conventional optical discs as biochemical analyzers (Valencia)
18 february 2011 - Silencing genes in bacteria: Researchers uncover target-dependent small RNA regulation pathway (Lisbon)
17 february-31 december 2011 - The ARNA Lab in Bordeaux (Bordeaux)
16 february-31 december 2011 - Plant-microorganism interactions : key papers published in Nature and Science (Toulouse)
16 february-31 december 2011 - A strong development of White Biotechnology in Toulouse (Toulouse)
3 february 2011 - III Cathedra of Corporate and Business Culture. Conference: Business Management in Times of Crisis, (Valencia)
1-4 february 2011 - Kick-off meeting of the LHCPhenoNet Initial Training Network (Valencia)
20-22 january 2011 - Colloque international Histoire du Cancer - 1750-1950 (Toulouse)
31 december 2010 - Patent Watch Newsletter – Health Science & Technologies December 2010 (Valencia)
9 december 2010 - RNAs & Cancer Seminar, December 9th at IECB (Bordeaux)
9-10 december 2010 - Systems Biology: Bridging the gaps between disciplines (Barcelona)
3 december 2010 - New book on protein folding and metal ions: mechanisms, biology and disease (Lisbon)
18-20 november 2010 - The First European Conference on Mesenchymal Stem Cells (MSC)
17 november 2010 - First International Conference on Biotechnology in the CV (Valencia)
15 november 2010 - II Spanish-Portuguese Image and e-Science in breast cancer (Valencia)
4-6 november 2010 - International Symposium on Nitric Oxide-cyclic GMP Signal Transduction in Brain (Valencia)
3-5 november 2010 - 3rd Clinical Trials on Alzheimer's Disease conference (CTAD) (Barcelona)
13 october 2010 - Biocat and Eurobiomed sign agreement to drive partnering (Barcelona)
12-16 september 2010 - 8th International Congress on Extremophiles (Lisbon)
9 september 2010 - Biocat organizes 'Barcelona Innovation workshops: NanoBiotechnology - IT for Biology & Health' (Barcelona)
8 september 2010 - New trends in pharmaceutical innovation analyzed at Summer School on Medicines (Barcelona)
23 july-17 september 2010 - ECCP 2010, European oncology partnering (Barcelona)
23 july-10 september 2010 - European Interbio project gives six grants to attend 'Summer School on Medicines' held in Toulouse a (Barcelona)
16 july 2010 - Southern Europe Biocluster, Euroregion’s scientific and economic network, officially launched (Barcelona)
13 july 2010 - Networking-Workshop (Barcelona)
5 july 2010 - Girona Science and Technology Park starts up international ‘Develop your talent’ program (Barcelona)
24-25 june 2010 - NOVEL TARGETING DRUGS AND RADIOTHERAPY – FRANCE (Toulouse)
16-19 june 2010 - 33rd European Cystic Fibrosis Conference (Valencia)
16 june 2010 - Nanotechnology and Nanoscience: a big technology on a tiny scale (Valencia)
16 june 2010 - Progress and challenges in Cystic Fibrosis Newborn Screening: Perspectives from USA, Europe and Spai (Valencia)
16-18 june 2010 - 10th International Workshop on Digital Mammography (IWDM2010) (Barcelona)
16 june 2010 - Nearly thirty renowned institutions join the Health University of Barcelona Campus to help it become (Barcelona)
6 june-10 may 2010 - 16th Annual Meeting of the Organization for Human Brain Mapping (Barcelona)
27-30 may 2010 - 1st International Congress on Controversies in Cryopreservation of Stem Cells, Reproductive Cells, T (Valencia)
27-29 may 2010 - International Symposium on Usher Syndrome and Related Diseases (Valencia)
24-26 may 2010 - 8th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice (Valencia)
19-21 may 2010 - Conference (Barcelona)
30 april-30 may 2010 - Institute of Photonic Sciences researches device for early cancer detection (Barcelona)
22-24 april 2010 - 6th European Conference on Comparative Neurobiology, ECCN6 (Valencia)
1 march 2010 - First Global Healthcare Institute created in Barcelona, to be led by Dr. Pedro Alonso (Barcelona)
   

Legal mentions | Site map | Contacts