MEMBERS' HIGHLIGHTS

The IECB technology platform in structural biology includes 6 NMR spectrometers, ranging from 300 to 800 MHz. Through the facility, custom services in liquid and solid NMR are provided to academic and industrial users, based on local scientific expertise:

• NMR of membrane lipids in the context of bicelles and membrane domains (rafts), atherosclerosis, and cellular signalling (e.g. nano-objects oriented by magnetic fields, sterols and phosphoinositids)
• Structures of nucleic acids, proteins, and protein/nucleic acid complexes
• NMR of peptides and membrane proteins involved in cancer, apoptosis or featuring particular antibiotic and antimicrobial properties (e.g.neu/erbB-2, Bax, Bcl-2, melittin, surfactin, cateslytin, etc.)
• NMR of colloids associated with the food or pharmaceutical industry (e.g. tannins with saliva proteins, lipopeptides with active nebulisable substances)
• Auto-assembly of amphiphilic molecules
• Synthesis and activity of natural substances of biological interest (e.g. phenols and quinols)
• Chemistry of solids, materials and alloys
• 2D, 3D and multidimensional NMR
• Residual dipolar coupling (RDC)
• Dynamics, 13C/15N relaxation

One of the distinctive instruments of the platform is the high field 800MHz liquid/solid NMR spectrometer, which is integrated within the French national network of large scale NMR facilities (TGIR-RMN). As part of this network, the instrument is made available for free to international users for 10% of its operating time. Experiment proposals for the 800MHz spectrometer should be submitted online at: www.tgir-rmn.org

In the frame of Interbio, IECB engineers and scientific experts in NMR are willing to set up both collaborative research projects and technical staff exchanges.

For further information and contact details, please visit the IECB

website: http://www.iecb.u-bordeaux.fr/index.php/en/biologie-structurale/rmn-des-liquides-et-des-solides